Faculty Directory
William M. Miller

Professor of Chemical and Biological Engineering

Director, Center for Engineering Sustainability and Resilience

Contact

2145 Sheridan Road
Tech E248
Evanston, IL 60208-3109

847-491-4828Email William Miller

Website

Center for Engineering Sustainability and Resilience


Centers

Northwestern-Argonne Institute of Science and Engineering (NAISE)

The Center for Water Research


Departments

Chemical and Biological Engineering


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Education

Ph.D. Chemical Engineering, University of California, Berkeley, CA

S.M. Chemical Engineering, MIT, Cambridge, MA

B.S. Chemical Engineering (Hons), Lehigh University, Bethlehem, PA


Research Interests

Environmental aspects of water, energy, and sustainability.

Environmental aspects of water, energy, and sustainability with a focus on ecosystem services provided by urban nature preserves and green infrastructure (GI) including water storage, flood mitigation, urban microclimate regulation, and air pollution mitigation. Data from a network of groundwater, surface water, and soil moisture sensors provides information on water storage and transport across Gensburg Markham Prairie (GMP a high quality remnant prairie owned by The Nature Conservancy and Northeastern Illinois University) as a function of precipitation history, season, and time for use in predicting GMP water storage and release dynamics to understand the impact for mitigating flooding in surrounding neighborhoods. Research in collabration with the Center for Neighborhood Technology in Chatham, the Chicago neighborhood with the most flood insurance claims in 2007-2011, focuses on the impacts of installing GI, such as rain gardens, in urban neighborhoods. (with Prof. Aaron Packman in Civi and Environmental Engineering)

Human and animal cell culture applications in biotechnology, medicine, and tissue engineering. 

Ex vivo expansion and controlled differentiation of hematopoietic (blood) stem and progenitor cells for transplantation therapies, with a focus on megakaryocytic cells and platelets.  Development of culture surfaces and microbioreactors that mimic aspects of the in vivo bone marrow niche to increase megakaryocytic differentiation and stimulate platelet release.  Analysis of mechanisms regulating hematopoietic differentiation, including epigenetics, protein acetylation, and transcription factor activity networks. Development of bioreactor systems for hematopoietic cell and platelet production. 

Development and characterization of bioreactor systems for the recellularization of organ scaffolds for eventual use in liver and kidney transplantation (with Prof. Jason Wertheim in Transplant Surgery)


Selected Publications

    "Energy Sprawl or Energy Efficiency: Climate Policy Impacts on Natural Habitat for the United States of America," R.I. McDonald, J. Fargione, J. Kiesecker, W.M. Miller, and J. Powell, PLoS ONE, 4: e6802 (11 pages) (2009).

    "Energy, Water and Fish: Biodiversity Impacts of Energy-Sector Water Demand in the United States Depend on Efficiency and Policy Measures," R.I. McDonald, J.D. Olden, J.J. Opperman, W.M. Miller, J. Fargione, C. Revenga; J.V. Higgins, and J. Powell, PLoS ONE, 7: e50219 (17 pages) (2012).

    "Three-Stage Ex Vivo Expansion of High-Ploidy Megakaryocytic Cells: Towards Large-Scale Platelet Production," S. Panuganti, A.C. Schlinker, P.F. Lindholm, E.T. Papoutsakis, and W.M. Miller, Tissue Eng. A, 19: 998-1014 (2013).

    "Profiling Deacetylase Activities in Cell Lysates with Peptide Arrays and SAMDI Mass Spectrometry," H.-Y. Kuo, T.A. DeLuca, W.M. Miller*, and M. Mrksich*, Anal. Chem., 85: 10635-10642 (2013) (Editors' Highlight). PMID: 24088168.

    "Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocyte and erythrocyte differentiation," M.T. Duncan, S. Shin, J.J. Wu, Z. Mays S. Weng, N. Bagheri*, W.M. Miller*, L.D. Shea*, Biotechnol. Bioeng. 111: 2082-2094(2014).

    "Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration," A.C. Schlinker, K. Radwanski, C. Wegener, K. Min*, W.M. Miller*, Biotechnol. Bioeng. 112:788-800(2015). NIHMSID: 744727.

    "Dual-purpose bioreactors for recellularization and maintenance culture of bioengineered kidney and liver scaffolds," J.S. Uzarski, B.M. Bijonowski, B. Wang, H.H. Ward, A. Wandinger-Ness, W.M. Miller*, J.A. Wertheim*, Tissue Engineering Part C. 21:1032-1043 (2015).

    “A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets,” A.F. Martinez, R.D. MacMahon, M. Horner, W.M. Miller, Biotechnl. Prog., 33:1614-1629 (2017) (cover image).

    “Enabling large-scale ex vivo production of megakaryocytes from CD34+ cells using gas-permeable surfaces,” A.F. Martinez, W.M. Miller, Stem Cells Translational Medicine, 8:658-670 (2019) (highlighted in Previews).

    “Characterization of soil profiles and elemental concentrations reveals deposition of heavy metals and phosphorus in a Chicago-area nature preserve, Gensburg Markham Prairie,” L.M. Hernandez Gonzalez, V.A. Rivera, C.B. Phillips, L.A. Haug, S.L. Hatch, L. Yeager, H. Chang, J. Alvarez, K.J. Gnaedinger, W.M. Miller, A.I. Packman, J. Soils and Sediments, 19:3817-3831 (2019).

    “A systematic review of the human health and social well‐being outcomes of green infrastructure for stormwater and flood management,” V. Venkataramanan, A.I. Packman, D.R. Peters, D. Lopez, D.J. McCuskey, R.I. McDonald, W.M. Miller, S.L. Young, J. Environmental Management, 246:868-880 (2019).

    “Soil hydrology drives ecological niche differentiation in a native prairie microbiome,” J.S. Griffin, L.A. Haug, V.A. Rivera, L.M. Hernandez Gonzalez, J.J. Kelly, W.M. Miller, G.F. Wells, A.I. Packman, FEMS Microbiology Ecology, https://doi.org/10.1093/femsec/fiz163 (2019).