Faculty Directory
Matthew Tresch

Professor of Biomedical Engineering

Professor of Physical Medicine and Rehabilitation


2145 Sheridan Road
Tech M320
Evanston, IL 60208-3107

Email Matthew Tresch


Biomedical Engineering

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Ph.D. Neuroscience, MIT, Cambridge, MA

B.A. Psychology, Wesleyan University, Middletown, CT

Research Interests

We examine the neural control of movement, focusing on the role of spinal circuitry.  We use an interdisciplinary approach in this research, using a combination of behavioral, biomechanical, and neurophysiological techniques.  Our current research examines the neural control of internal joint variables, evaluating the hypothesis that the nervous system actively regulates the stresses and strains within joints in order to minimize injury. We examine this issue using biomechanics, characterizing how muscles affect the stresses and strains within joints; using behavioral studies, characterizing how the CNS adapts kinematics and muscle activations to compensate for alterations in joint structures; and using electrophysiological studies, examining the neural systems involved in regulating joint stresses and strains.

We are also developing neuroprostheses for restoring functional movements following spinal cord injury. This is collaborative work with Dr. Lee Miller.  Previous work from his lab has shown the potential of cortically controlled FES: using cortical predictions of muscle activation to drive stimulation of paralyzed muscles, thereby restoring natural control of a paralyzed animals’ own limb.  We are developing these procedures in a rodent model, examining whether this approach can be used to restore the hindlimb movements underlying locomotion in animals paralyzed by spinal cord injury.

Selected Publications

  • Filipe O. Barroso, Bryan Yoder, Josephine Wallner, Maria Jantz, Pablo Tostado, Evonne Pei, Vicki Maria Tysseling, Lee E Miller, Matthew C Tresch, “Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats”, Biosystems and Biorobotics, (2019)
  • Manish Sreenivasa, Francisco J. Valero-Cuevas, Matthew C Tresch, Yoshihiko Nakamura, Alfred C. Schouten, Massimo Sartori, “Editorial”, Frontiers in Computational Neuroscience, (2019)
  • Filipe O. Barroso, Bryan Yoder, David Tentler, Josephine J. Wallner, Amina A. Kinkhabwala, Maria K. Jantz, Robert Davisson Flint, Pablo M. Tostado, Evonne Pei, Ambika D.R. Satish, Sarah K. Brodnick, Aaron J. Suminski, Justin C. Williams, Lee E Miller, Matthew C Tresch, “Decoding neural activity to predict rat locomotion using intracortical and epidural arrays”, Journal of Neural Engineering, (2019)
  • Cristiano Alessandro, Benjamin A. Rellinger, Filipe Oliveira Barroso, Matthew C Tresch, “Adaptation after vastus lateralis denervation in rats demonstrates neural regulation of joint stresses and strains”, eLife, (2018)
  • Qi Wei, Dinesh K. Pai, Matthew C Tresch, “Uncertainty in limb configuration makes minimal contribution to errors between observed and predicted forces in a musculoskeletal model of the rat hindlimb”, IEEE Transactions on Biomedical Engineering, (2018)
  • Thomas G Sandercock, Qi Wei, Yasin Y Dhaher, Dinesh K. Pai, Matthew C Tresch, “Vastus lateralis and vastus medialis produce distinct mediolateral forces on the patella but similar forces on the tibia in the rat”, Journal of Biomechanics, (2018)
  • Philippe Saltiel, Andrea D?Avella, Matthew C Tresch, Kuno Wyler, Emilio Bizzi, “Critical points and traveling wave in locomotion”, Frontiers in Neural Circuits, (2017)
  • Vicki Maria Tysseling, D. A. Klein, R. Imhoff-Manuel, M. Manuel, Cj Heckman, Matthew C Tresch, “Constitutive activity of 5-HT2c receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment”, Journal of Neurophysiology, (2017)